水溶性维生素在利巴韦林治疗小儿手足口病中的疗效

Effect of Water-Soluble Vitamins in the Treatment of Ribavirin on Hand-Foot-Mouth Disease

目的观察水溶性维生素在利巴韦林治疗小儿手足口病(HFMD)中的作用。方法随机选取我院诊治的手足口病患儿115例,随机分两组,对照组55例给予退热、补液及利巴韦林静滴治疗;治疗组60例,在对照组基础上加用水溶性维生素静滴,观察两组临床疗效、治愈时间、退烧时间、溃疡或口腔疱疹愈合时间及不良反应。结果治疗组的临床总有效率达95.00%,显著高于对照组(83.64%),差异有统计学意义(P<0.05);治疗组的治愈时间、退烧时间及溃疡或口腔疱疹愈合时间均显著短于对照组,差异有显著性(P<0.05),两组均未见明显不良反应。结论水溶性维生素可增强利巴韦林治疗小儿手足口病的临床疗效,缩短疗程且安全性高。

Objecave To observe the effect of water-soluble vitamins in the treament of ribavirin on hand-foot-mouth disease （HFMD）. Methods 115 cases with HFMI） were selected and divided into two groups randomly. 55 cases in the control 8;roup were treated with antifebrile, fluid injection and ribavirin. 60 cases in the treatment group were treated withboth ribavirin and water-soluble vitamin injection respectively. The clinical effect and the time of temperature recovery, rash disappearance and side effects were observed between the two groups. Results The total effective rate was 95.00% in the treatment group, significantly higher than 83.64% in the control group （P 〈0.05）. The time of cure, temperature recovery and rash disappearance was significantly shorter than that in the control group （P 〈0.05）. The adverse reactions was not found in both groups. Conclusions Water-soluble vitamins can strengthen ribavirin therapy effect on HFMD, shorten treatment course with high safety.