乌司他丁与甲强龙联合救治百草枯中毒患者的临床研究

Clinical Study of Ulinastatin Combined with Methylprednisolone in the Treatment of Patients with Paraquat Poisoning

目的探讨乌司他丁与甲强龙在百草枯中毒患者中的联合应用价值。方法选取2011年6月至2012年6月期间我院收治的百草枯中毒患者88例,将患者随机分为研究组和对照组,每组44例。两组患者经明确诊断后均给予一般支持性治疗,对照组患者在此基础上给予甲强龙的药物治疗,而研究组患者则在对照组基础上再给予乌司他丁进行药物联合治疗,并分别对两组患者的临床治疗情况、并发症发生情况、辅助仪器使用情况进行比较和分析。结果研究组与对照组相比,其患者的治愈率和总有效率均明显提高,而无效率则明显降低,差别均具有统计学意义(P<0.05);其患者低氧血症和Ⅰ型呼吸衰竭的发生比率均显著降低;与此同时,机械通气等辅助仪器的使用比率均明显减少,差别均具有统计学意义(P<0.05)。结论乌司他丁联合甲强龙救治百草枯中毒,其疗效确切效果显著,可作为百草枯中毒患者较为理想的联合用药方案。

Objective To explore the application value of ulinastatin combined with methylprednisolone in the treatment of patients with paraquat poisoning. Methods 88 patients with paraquat poisoning in our hospital from June 2011 to June 2012 were selected and randomly divided into the study group and the control group with 44 cases in each group. All the patients were given general supportive therapy after definitive diagnosis. The patients in control group were treated with methylprednisolone medication, while patient in study group were treated with methylprednisolone combined with ulinastatin treatment. The clinical situation, complications and auxiliary instrument usage of two groups were compared and analyzed. Results Compared with control group, the efficiency and total efficiency of patients in study group were significantly improve, and inefficiency was decreased significantly, there were statistically significant （P 〈0.05）. At the same time, the patients with hypoxemia and type I respiratory failure rate, and the use of mechanical ventilation aids rate were significantly reduced, there were statistically significant （P 〈0.05）. Conclusions Ulinastatin combined with methylprednisolone in the treatment of patients with paraquat poisoning has curative and remarkable effect. It can be used as the ideal combination regimens for paraquat poisoning patients.