支气管哮喘患者血清维生素D与气道炎症关系探讨

In serum of patients with bronchial asthma and airway inflammation of vitamin D

目的探讨血清维生素D浓度与支气管哮喘血清炎症因子及哮喘急性发作次数的关系。方法选取支气管哮喘患者200例,检测血清维生素D、IL-2及TNF-α浓度,记录近2年哮喘急性发作的次数,研究血清维生素D浓度与IL-2、TNF-α及哮喘急性发作次数的关系。结果支气管哮喘合并低维生素D患者占51.5%,其中合并低维生素D患者支气管哮喘急性发作次数及IL-2、TNF-α明显高于不合并低维生素D患者,差异有显著性(P<0.05)。结论血清维生素D与气道炎症、支气管哮喘急性发作次数密切相关。

Objective To investigate the relationship of serum vitamin D and airway inflammation in bronchial asthma patients. Methods 200 eases of bronchial asthma patients tested serum vitamin D, IL-2 and TNF - α concentration, recording the number of acute attack of asthma in two years, to implore relationship of serum vitamin D and IL-2, TNF - α. Results bronchial asthma complicated with low vitamin D＇patients accounted for 51.5%, which merged with low vitamin D in patients with acute attack of bronchial asthma and the number of IL-2, TNF - α were higher than those with low vitamin D patients, （ P 〈 0. 05 ）. Conclusion The serum vitamin D is closely related to airway inflammation and acute attack frequency in bronchial asthma patients.