噻托溴铵联合舒利迭治疗老年重度持续支气管哮喘的临床观察

Clinical observation of elderly patients with severe persistent bronchial asthma treated by tiotropium plus seretide

目的比较噻托溴铵联合舒利迭治疗老年重度持续支气管哮喘的有效性。方法 42例老年重度持续支气管哮喘病例随机分成两组,分别使用噻托溴铵联合舒利迭(50/250)(治疗组)与单用舒利迭(50/250)(对照组)治疗4周,在治疗前及治疗后观察临床症状和肺功能的改变。结果两组患者临床症状和肺功能均较治疗前显著改善(P<0.01),以联合治疗组改善最为明显(P<0.01)。结论噻托溴铵联合舒利迭(50/250)治疗老年重度持续支气管哮喘能更有效的改善临床症状和肺功能。

Objective To compare the efficiency of tiotropium plus seretide （50/250） and seretide （50/250） only oll elderly patients with severe persistent bronchial asthma. Methods 42 elderly patients with severe persistent bronchial asthma were randomly di- vided into two groups. The therapy group was treated with tiotropium plus seretide and the cotrol group with seretide only for 4 weeks. The clinical symptoms and pulmonary function before and after the treatment were observed. Results The clinical symptoms and pulmonary function of the two groups after treatment were both better than before （ P 〈 0. 01 ）, but the improvement of the therapy group was more pronounced in the therapy group than in the control group （ P 〈 0.01 ）. Conclusion The treatment of tiotropium plus seretide is a very effective way for elderly patients with cwith severe persistent bronchial asthma.