噻托溴铵吸入治疗AECOPD的临床观察

Clinical observation of Tiotropium Bromide Powder in the treatment of acute exacerbation of chronic obstructive pulmonary disease

目的探讨噻托溴铵治疗AECOPD患者的临床疗效。方法选择78例AECOPD患者,随机分为常规治疗组(对照组)37例和噻托溴铵治疗组(治疗组)41例,治疗组应用噻托嗅铵18μg吸入,1次/天,观察两组患者治疗前后症状、呼吸困难评分及肺功能变化。结果两组有效率达100%,且治疗组较对照组改善更明显,治疗后两组临床症状、呼吸困难评分和肺功能等比较,差异有统计学意义(P<0.05)。结论噻托溴铵吸入治疗AECOPD,能明显缓解患者症状,改善肺功能,是治疗AECO-PD的有效选择。

Objective To observe the effects of Tiotropium Bromide Powder in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease. Methods There were 78 cases of AECOPD patients who were divided into treatment group（41 ca- ses） and control group（37 cases）randomly, the treatment group received inhaling of tiotroplum 18 μg every day, the changes of clinical manifestations ,dyspnea scores and lung function was observed before and after treatment. Results The effective rate was 100% in the two groups, and the values of clinical symptoms, dyspnea scores and lung function in the both groups were statistically significant after the treat- ment （ P 〈 0. 05 ）. Conclusion Tiotrepium can improve the AECOPD patient＇ s lung function and alleviate the clinical symptoms obvious- ly,and improve their life quality. It is an effective choice for treatment of patients with AECOPD.