肺结核患者抗结核药物治疗不良反应

The monitoring of adverse reaction in patients with pulmonary tuberculosis treated by anti-tuberculosis drugs(a report of 247cases)

目的探讨肺结核在抗结核药物治疗过程中发生的不良反应。方法对247例行抗结核药物治疗的肺结核患者出现不良反应进行分类分析。结果不良反应主要表现为肝肾功能损害,消化道症状和中枢神经症状等;年龄超过50岁者不良反应发生率明显高于年龄低于50岁者(P<0.05)。结论肺结核患者使用抗结核药治疗应加强督导和随访,定期复查肝肾功能,及时有效处理药物不良反应。

Objective To investigate the adverse reaction of patients with pulmonary tuberculosis during the processes of anti-tu- berculosis drug treatment, and provide the evidence for the development of effective prevention and treatment measures. Method The adverse reactions of 247 patients with pulmonary tuberculosis treated with anti-tuberculosis drug therapy were classified and statistical ana- lyzed. Results The main adverse reactions were liver and kidney dysfunction, gastrointestinal symptoms and nervous symptoms. The in- cidence of adverse reactions in patients over the age of 50 years was significantly higher than that of patients under the age of 50 years （ P 〈 0.05 ）. Conclusion The treatment of anti-tuberculosis drug in patients with pulmonary tuberculosis should be strengthened supervision and follow-up, reviewing the function of liver and kidney regularly, adverse and drug reactions should be treated timely and effective, par- ticularly patients over the age of 50 years.