非小细胞肺癌中CD147和MMP2的表达及意义

Expressions of CD 147 and MMP2 in None Small Cell Lung Cancer and its Significance

目的探讨CD147和MMP2在非小细胞肺癌(NSCLC)中的表达及意义。方法应用免疫组织化学方法 SP法检测80例NSCLC及20例癌旁组织中CD147和MMP2的表达情况。结果 CD147和MMP2在20例癌旁组织中阳性表达率分别为20%、15%;CD147、MMP2在NSCLC中的阳性表达率分别为66.3%、70.0%(P均<0.01)。CD147和MMP2的表达均与NSCLC患者的临床分期及淋巴结转移相关(P均<0.05),与组织学分型及肿瘤分化程度无关(P均﹥0.05)。结论 CD147和MMP2在NSCLC中高表达,两者在NSCLC的发生发展中可能发挥着重要作用。

Objective To investigate expressions of CD147 and MMP2 in none small cell lung caner and its significance. Method The expressions of CD 147 and MMP2 in 80 cases with none small cell lung caner and 20 cases with paraneoplastic of the none small cell lung caner were detected by immunohistoehemical SP method. Results In 20 specimens with paraneoplastic of the none small cell lung ca- ner, the expressions of CD147 and MMP2 were 20% and 15% （all P 〈0. 01 ） , The expressions of CD147 and MMP2 in none small cell lung caner were 66. 3% and 70. 0% （ all P 〈0. 05）. The expressions of CD147 and MMP2 in none small cell lung cancer were related to clinical stage and lymph node metastases and not related to tumor histological type and tumor differentiation. Expression of CD147 was pos- itively correlated to MMP2 （r =0. 738）. Conclusion CD147 and MMP2 expressions were high in none small cell lung caner, and they play important roles in carcinogenesis of none small cell lung caner.