FEV_1%与FEV_1/FVC作为COPD气流阻塞判定指标的比较研究

The comparison of FEV_1% with FEV_1/FVC as judging index for airflow obstruction of COPD.

目的 对FEV1%与FEV1/FVC作为COPD气流阻塞判断标准进行比较分析。方法 对 15 8例慢性支气管炎和肺气肿患者 ,34例限制性通气功能障碍疾病的患者及 34例正常人的肺功能进行前瞻性的分析研究。结果 作为COPD气流阻塞判断指标 ,FEV1%与FEV1/FVC呈高度直线正相关 (P <0 0 1) ,FEV1/FVC敏感性高 ,漏诊率低。作为分级标准 ,两者的百分比并不一致 ,FEV1/FVC受FEV1与FVC下降的不一致影响 ,与FEV1%比较 ,中度略有上升 ,重度则明显增高。结论 在确定有无气流阻塞诊断COPD时 ,FEV1/FVC较好 ,在气流阻塞程度分级时 。

Objective To compare FEV 1 with FEV 1/FVC as judging criteria for airflow obstruction of COPD.Methods We prospectively analyzed the results of pulmonary function tests in 158 patients with chronic bronchitis and emphysema,34 patients with restrictive ventilatory dysfunction and 34 healthy persons.Results As a judging index for airflow obstruction of COPD,FEV 1% was correlated well with FEV 1/FVC(P<0\^01),which had a high sensitivity and low missing rate.As a grading criteria,the percentage of both were not similar.Compared with FEV 1%,FEV 1/FVC increased slightly in moderate degree and significantly in severe degree due to being influcenced disproportionately by FEV 1 and FVC.Conclusion FEV 1/FVC is a better index in judging whether or not the patient has airflow obstruction in order to diagnose COPD,while FEV 1% is a better indicator in grading the degree of airflow obstruction.