2型糖尿病肾病与白细胞介素18相关性分析

Correlationship between Type 2 Diabetic Nephropathy and Interleukin-18

为探讨、分析2型糖尿病肾病(DN)与白细胞介素18(IL-18)的相关性,将108例糖尿病患者平均分为3组:DN大量蛋白尿组、DN微量蛋白尿组和单纯糖尿病组,另选择36例健康体检者作为对照组。分别检测各组患者血清IL-18、空腹血糖(FPG)、糖化血红蛋白(HbA1C)和餐后2 h血糖(2hPG),结果为:DN大量蛋白尿组和DN微量蛋白尿组患者血清IL-18明显高于单纯糖尿病组和对照组(P<0.01);单纯糖尿病患者血清IL-18明显高于对照组(P<0.01);且血清IL-18浓度与FPG、HbA1C和2hPG呈正相关(P<0.01)。血清IL-18可以反映2型糖尿病肾病的病情进展。

Objective： to explore and analyze the correlationship between type 2 diabetic nephropathy（DN） and interlenkin - 18 （ IL - 18）. Methods： 108 patients with diabetes were divided into three groups ： DN macroalbuminuria group, DN mieroalbuminuria group, and 2 diabetic patients group without albuminuria. each with 36 cases. 36 health volunters were selected as healthy control group. Serum IL - 18, fasting plasma glucose （FPG） , glyeosylated hemoglobin （ HbA1C ） and 2 - hour postprandial blood glucose （2hPG） were detected in all the above groups respectively. Results： Serum IL - 18 in both DN proteinuria group and DN microalbuminuria group was significantly higher than that in pre - DN group and control groups （P 〈 0. O1 ） , DN early levels of serum IL- 18 was significantly higher （P 〈0.01 ） and serum IL- 18 in pre -DN group was significantly higher than that in control groups （P 〈0.01 ）. Furthermore the concentration of serum IL- 18 was positively correlated with FPG, HbA1C and 2hPG（P 〈0. O1 ）. Conclusion：The serum IL - 18 may reflect the development of type 2 diabetic nephropathy.