复脉抗衰注射液对缺血性心肌病免疫功能的影响

Effect of Fumai Kangshuai injection on immunologic function in patients with ischemic cardiomyopathy

目的 :研究复脉抗衰注射液对缺血性心肌病患者体液免疫 (Ig G、Ig A、Ig M)、细胞免疫 (T细胞亚群 )及可溶性白细胞介素 - 2受体 (s IL- 2 R)的影响。方法 :49例患者随机分为常规组和复脉抗衰治疗组 (治疗组 )。常规组采用常规治疗 ,治疗组在常规治疗的基础上加用复脉抗衰注射液。两组治疗前后均采肘静脉血测定 T细胞亚群、Ig M、Ig A、Ig G、s IL- 2 R,同时进行临床疗效评价。结果 :治疗前 49例患者的血清 Ig G、Ig A、Ig M均高于正常组 (P<0 .0 5 ) ,两组患者的 CD3、CD4、CD4/CD8比值均低于正常组 (P <0 .0 5 )。 s IL - 2 R高于正常组。用药后 ,治疗组的CD4和 CD4/CD8比值上升 (P <0 .0 5 ) ,s IL - 2 R明显下降 (P <0 .0 5 )。血清 Ig G、Ig A、Ig M均有所下降但无统计学意义 ,而常规组治疗后各项指标均无明显变化 (P >0 .0 5 )。结论 :复脉抗衰注射液具有改善患者免疫功能的作用。

Objective:Evaluating the effects of Fumai Kangshuai (FMKS) injection on serum immunoglobulins IgG IgA IgM and T lymphocyte subgroups and soluble interleukin 2 receptor (sIL 2R) in patients with ischemic cardiomyopathy.Method:49 patients were randomly divided into two treatment groups (routine and FMKS).These parameters were measured in 20 healthy subjects as control and patients of two treatment groups.Result:①Before treatment both treatment groups IgG,IgA,IgM and sIL 2R were higher significantly and CD 3,CD 4,CD 4/CD 8 radio were lower than that of healty control (P< 0.01 ) respectively.②The levels of CD 4,CD 4/CD 8 redio were increased significantly in FMKS treatment group (P< 0.05 ) and the levels of serum IgG IgA IgM were decreased in FMKS treatment group,but the difference was not significant (P> 0.05 ).These parameters were not changed in the routine group.Conclusion:Fumai Kangshuai injection could improve immunlogic function in patients with ischemic cardiomyopathy.