利尿剂联合β受体阻滞剂治疗慢性心力衰竭的临床效果评价

Evaluation of the Clinical Effect of Diuretics Combined β-adrenergic Receptor Blockers on the Treatment of Chronic Heart Failure

目的:评价利尿剂联合β受体阻滞剂(β-RB)治疗慢性心力衰竭(CHF)的临床疗效。方法:将127例CHF患者随机分为三组,分别以利尿剂(A组)、β-RB(B组)和利尿剂+β-RB(C组)治疗,比较各组患者治疗后心功能指标、心室重塑情况及临床疗效。结果:治疗8周后,C组LVEF、SV、CO的水平均显著高于A组和B组,但其HR水平显著低于A组和B组,差异均具有统计学意义(P<0.05);C组LVESV、LVS、LVEDV、LVD水平均显著低于A组和B组,差异均具有统计学意义(P<0.05);A组治疗总有效率为77.5%,B组治疗总有效率为78.0%,C组治疗总有效率为93.5%,C组治疗总有效率显著高于与A组和B组,差异均具有统计学意义(P<0.05)。结论:利尿剂联合β-RB治疗CHF的临床效果显著优于利尿剂和β-RB单用的临床效果。

ABSTRACT Objective： To evaluate the clinical effect of Diuretics combined β-adrenergic receptor blockers on the treatment of chronic heart failure. Methods： 127 patients with chronic heart failure were divided into three groups randomly, they were treated by Diuretics （A group）, β-adrenergic receptor blockers （B group） and both two （C group）, the cardiac function index, the ventricular remodeling situation and the clinical efficacy were compared among the three groups after 8-week treatment. Results： After 8-week treatment, the level of LVEF, SV, CO in C group were all significantly higher （P〈0.05） than those in A group and B group, the level of HR in C group was significantly lower （P〈0.05） than that in A group and B group; the level of LVESV, LVS, LVEDV, LVD were all significantly lower （P〈0.05） than those in A group and B group. The total effective rate of A group was 77.5%, which was 78.0% in B group, 93.5% in C group, the total effective rate of C group was significantly higher （P 〈0.05） than those in A group and B group. Conclusion： It was showed that Diuretics combined β-adrenergic receptor blockers was more effective than Diuretics or β-adrenergic receptor blockers alone on the treatment of chronic heart failure. Key words： Chronic heart failure; Diuretics; β-adrenergic receptor blockers; Combination therapy; Clinical efficacy