聚丙交酯(PL)/丙交酯-聚乙二醇共聚物(PLEG)共混微球的制备、表征及释药行为

Preparation, Characterization and Drug Release Characteristics of Poly(lactide)(PL)/Poly(lactide co polyethylene glycol)(PLEG) Blend Microspheres

PL 与 PL EG是生物降解、生物相容的高分子材料 ,利用它们作为药物控释载体已引起人们广泛的重视。我们合成了含不同 PEG链段长度的 PL EG共聚物 ,并利用 PL 与 PL EG这两种材料各自的优点制备载有人绒毛促性腺激素 (h CG)的共混微球以提高 h CG在微球中的包埋率 ,结果表明采用 P(L- co- PEG6 0 0 0 ) (90 :10 )与 PL共混制备得到的微球中 ,h CG的包埋率高于单独用 PL 或 PL EG制得的微球。h CG的体外释放为突破 -缓释过程 。

PL and PLEG are biodegradable, biocompatible polymers. They have been widely used for controlled release of drugs. We synthesized PLEG copolymers containing PEG segments with various molecular weight and prepared hCG loaded PL/PLEG blend microspheres to improve hCG entrapment efficiency. It was shown that the hCG entrapment effciency of PL/PLEG microspheres was higher than that of PL or PLEG microspheres when P(L co PEG6000)(90∶10) was used. In vitro release test showed that the release of hCG was a burst slow process, which was thought to be good for antigens to produce antibodies.