磁敏感加权成像在帕金森病诊断中的应用研究

Clinical value of susceptibility weighted imaging in the diagnosis of Parkinson disease

目的应用磁敏感加权成像技术（SWI）分析帕金森病（PD）患者的脑基底节和红核铁含量的变化，探讨SWI在PD诊断中的应用价值。方法对56例帕金森病患者及40例健康对照组在3．0T磁共振成像系统上行磁敏感加权成像，经过SWI处理软件得到相应的相位图像，测量脑基底节各个区域和红核的信号值，并与对照组进行对比观察。结果PD组与健康对照组相比较，尾状核（0．05±0．01与0．04±0．01，t=1．991）、壳核（-0．42±0．13与-0．25±0．07，t=2．544）和苍白球（-0．23±0．07与-0．11±0．02，t=2．893）的信号值差异均有统计学意义（P〈0．05）。结论利用SWI测定脑部基底节各区域的铁沉积信号，在帕金森病的诊断中具有临床应用价值。

Objective To explore the application value of susceptibility weighted imaging （SWI） in the Parkinson disease （PD） diagnosis by analysis the changes of brain iron content of the basal ganglia and red nucleus. Methods Totally 56 cases of patients with PD and 40 cases of normal control group were diagnosed by SWI with the 3.0 T magnetic resonance imaging system, the corresponding phase image by using SWI processing software was obtained, the signal values of the various regions of the brain basal ganglia and red nucleus were measured and compared. Results In comparison of PD group with normal control group, the signal values showed differences in caudate （0.05±0.01vs. 0. 04±0.01, t= 1. 991）, putamen（-0. 42±0.13 vs. -0.25±0.07, t=2. 544） and globus pallidus（- 0. 23 ＋ 0. 07 vs. -0.11±0.02, t=2.893） （all P〈0.05）. Conclusions Determining the iron deposition signal of the various regions of the brain basal ganglia by SWI is valuable in the clinical diagnosis of Parkinson＇s disease.