黄芩茎叶总黄酮调血脂作用研究

Studies on the Blood Lipid Regulating Effects of the Total Flavonoid from Baikal Skullcap (Scutellaria baicalensis) Stem and Leaf

黄芩茎叶总黄酮 (以下简称总黄酮 )是黄芩茎叶的主要有效部位。动物实验结果证明 ,在给大鼠喂以高脂饲料的同时 po总黄酮能明显抑制血清总胆固醇 (TC)、甘油三酯 (TG)和低密度脂蛋白 (L DL- C)的升高。对已经形成高脂血症的大鼠 ,也能明显降低血清 TC、TG、L DL- C的水平及动脉粥样硬化指数 (AI,AI=TC-HDL- C/ HDL- C)。

Blood lipid regulating effects of the total flavonoid (TF) from the stem and leaf of Scutellaria baicalensis Georgi were studied. Experimental results showed that TF could obviously inhibit the elevation of serum total cholesterol (TC). Triglyceride (TG) and LDL C in rats fed with high fatty diet. TF also obviously lowered the levels of TC, TG, LDL C and atherosclerotic index (AI) (TC-HDL C/HDL C) of hyperlipidemic rats. These results suggested that TF had significant preventive and therapeutic effects on experimental hyperlipidemic rats.