鼻咽癌患者SPECT腮腺功能的测定

Determination of the Parotid Gland Function by SPECT in Patients with Nasopharyngeal Cancer

目的探讨ＳＰＥＣＴ腮腺功能测定评价鼻咽癌患者不同设野放射治疗后腮腺功能损伤情况的可行性．方法选取 ３１例鼻咽癌患者作研究对象，行单纯放射治疗，其中 ２０例行双耳前野放疗， １１例行双耳前野加鼻前野放疗．患者在放疗前和放疗后均用ＳＰＥＣＴ检测其腮腺功能．结果常规鼻咽双耳前野加鼻前野放射治疗和双耳前野放射治疗的腮腺摄取功能极度损伤率分别为４．５％（１／２２）和２７．５％（１１／４０）；排泌功能极度损伤率分别为３６．４％（８／２２）和６５．０％（２６／４０），两对照组比较均有统计学差异（ｐ＜０．０５）．结论ＳＰＥＣＴ腮腺功能测定是评价鼻咽癌患者放射治疗后腮腺功能损伤程度的敏感、适用的方法；腮腺损伤以排泌功能损伤为主，放射剂量愈大，腮腺的摄取和排泌功能损伤愈严重．

Objective To evaluate the possibility of determination of the parotid gland function of NPC patients treated with radiotherapy in different field by SPECT. Methods 31 NPC patients were divided two groups. 20 patients were treated in both front ear field and 11 patients were treated in both front ear field plus front nose field. Parotid gland function of NPC patients were examined by SPECT at the begining the and the end of radiotherapy. Results Extreme damage rates of parotid absorbing function of both front earsa plus front nose group and both front ear group were 4. 5% (1/22) and 27.5% (11/40) respectively; parotid gland secretory function extreme damage rate were 36.36% (8/22) and 65.0% (26/40). There are significantly differences between the two groups(p<0.05). Conclusions SPECT is a sensitive. and useful method in determining the parotid gland function of NPC treated by radiotherapy. Parotid gland secretory function extreme damage rate is primary. The larger of the dose, the more serious of the parotid gland function damage.