健脑通络胶囊对血管性痴呆大鼠大脑神经递质的影响

Influences of the Prescription of Jiannao Tonluo Capsule on Neurotransmitter in Rat Models of Dementia

目的:观察健脑通络方(JNTL)对血管性痴呆大鼠大脑神经递质的影响,探讨其治疗血管性痴呆的作用机理。方法:以颈内动脉暂时夹闭加颈外动脉注射栓子方法造成多发性脑梗塞,加注山莨菪碱,以记忆力检测模型,测量各组大鼠脑内去甲肾上腺素、乙酰胆碱、多巴胺、5-羟色胺的含量。结果:给药组大脑皮层的各种递质含量明显增加。结论:JNTL具有提高血管性痴呆动物大脑皮层的神经递质含量,具有一定的健脑益智的实验室基础。

To study the influence of the prescription of Jiannao Tongluo Capsule (JNTL) on erebral neurotran-simitter in experimental rat dementia models, and to research the mechanism. The multiple cerebral infarction was caused by temporary clamp to internal carotid artery and injection of emboli to external carotid artery in rats, accompanied with injection of scopolamine. Rat memory, and cerebral neurotransmitters, including no-radrenaline, acetylcholine, dopamine, 5-hydroxytryptamine, were determinated. JNTL can increase the content of the above cerebral neurotransmitters in dementia rats and provide laboratory verification of the clinical application.