手术联合^125I密封籽源植入治疗唾液腺恶性肿瘤

Operation plus brachytherapy of iodine 125 seeds implantation for salivary gland malignant tumors

目的探讨手术联合125I密封籽源植入治疗唾液腺恶性肿瘤的效果。方法2006年6月至2011年6月，解放军总医院口腔颌面外科105例唾液腺恶性肿瘤患者，联合手术在术中、术后将^125I密封籽源植入到切除后瘤床内，通过影像学检查观察疗效及其并发症的回顾性研究。结果本组105例患者随访观察12—60个月者92例，其中无变化者占8．7％（8／92），近期有效率（CRPR）高达91．3％（84／92）。并发症主要为疼痛、黏膜溃疡，皮肤发黑，放射性骨髓炎。结论手术联合^125I密封籽源植入治疗唾液腺恶性肿瘤是一种有效、方便而且不良反应小的治疗方法。

Objective To evaluate the efficacy and safety of brachytherapy plus operation for salivary gland malignant tumors. Methods From June 2006 to June 2011, a total of 105 patients with salivary gland malignant tumors undergone brachytherapy by implantation of iodine 125 seeds. The effectiveness was evaluated by periodical radiological film and computed tomography. The complications were analyzed. Results Among them, 92 patients were observed for 12 - 60 months. The rates of clinical response rate （CRPR） and no change （NC） were 91.3% （84/92） and 8.7% （ 8/92 ） respectively of the patients. Pain, mucosa ulcer, skin darkness and radiation osteomyelitis were common complications. Conclusion The combined regimen of operation and brachytherapy of iodine 125 seed implantation for salivary gland malignant tumors is quite effective and convenient. And it has fewer complications.