CKD非透析患者CVD的发生情况及影响因素分析

目的研究慢性肾脏病（CKD）非透析患心血管疾病（CVD）的发生情况及危险因素。方法分析695例cKD非透析患者基础资料、实验室指标、心脏彩色超声指标及其与既往CVD病史之间的关系，研究CKD非透析患者CVD的发生情况，探讨与其相关的危险因素。结果695例患者中226例（32．5％）有CVD既往史，Logistic回归分析显示，年龄、GFR、SBP、DBP、颈总动脉内径、颈总动脉IMT及分叉部IMT是cKD非透析患者CVD的独立危险因素。结论cKD非透析患者CVD的发生率较正常人显著升高，年龄、高血压、脂质代谢紊乱、微炎症状态、贫血、低蛋白血症、钙磷代谢紊乱等因素与CKD患者CVD的发生、发展密切相关。

Objects This study was designed to observe the prevalence of cardiovascular disease and its influencing factors in non-dialysis CKD patients. Method 695 CKD patients and 52 controls were enrolled in the present study. We investigated CVD morbidity through clinical data collection, laboratory tests, echocardiography. Results The morbidity of CVD was much higher in non-dialysis CKD patients. Many traditional and nontraditional cardiovascular risk factors may contribute to the excessive risk of CVD, such as age, hypertension, dyslipidemia, inflammation, anaemia, hypoproteinemia and secondary hyperparathyroidism. Conclution The prevalence of CVD is relatively high in CKD patients. Age, hypertension, lipid metabolism disorders, micro-inflammatory state, anemia, hypoproteinemia, calcium and phosphorus metabolism disorders are the independent risk factors for CVD in non-dialysis CKD patients.