CRRT对重症急性胰腺炎患者脂联素TNF-α和CRP的影响

目的探讨重症急性胰腺炎（SAP）患者脂联素、TNF-α和CRP水平的变化特点及连续性肾脏替代疗法（CRRT）对其影响。方法按照平行对照设计原理，将所有66例患者分为对照组和CRRT组。对两组患者的相关临床资料及脂联素、TNF-α和CRP水平进行比较。结果与CRRT组患者比较，对照组患者第1天TNF-α和CRP水平均明显升高（均P〈0．05），脂联素水平明显降低（P〈0．05）；与CRRT组患者比较，对照组患者第2、3天TNF-α和CRP水平均明显升高（均P〈0．01），脂联素水平明显降低（均P〈0．01）；治疗前两组患者脂联素、TNF-α和CRP水平，差异无统计学意义（均P〉0．05）；在年龄、性别、APACHEII评分等方面两组差异无统计学意义（均P〉0．05）。结论CRRT能通过降低TNF-α和CRP水平及升高脂联素水平，对SAP患者起到较好的治疗作用。

Objective To explore the changes of adiponectin, tumor necrosis factor-α, C-reactive protein as well as the effects of CRRT in patients with severe acute pancreatitis （ SAP ） . Methods 66 patients with SAP Were collected.The patients were divided into control group and CRRT treatment group, the characters of clinical and the Level of adiponectin, tumor necrosis factor-α, C-reactive protein were compared between the two groups. Results the lever of tumor necrosis factor-α, C-reactive protein were significantly higher in control group group than that in CRRT treatment group in day 1 （ both P〈0.05 ） , the lever of adiponectin was significantly lower in control group group than that in CRRT treatment group in day 1 （ bothP〈0.05 ） ; the lever of tumor necrosis factor-α C-reactive protein were significantly higher in control group group than that in CRRT treatment group in day 2 and day 3 （ allP〈0.01 ） , the lever of adiponectin were significantly lower in control group group than that in CRRT treatment group in day 2 and day 3 （ bothP〈0.01 ） ; there is no significant differences between control group and CRRT treatment group in adiponectin, tumor necrosis factor-α, C-reactive protein before treatment （ all P〉 0.05 ） ;there is no significant differences between control group and CRRT treatment group in Age, gender, APACHE II score （ all P〉0.05 ） . Conclusion CRRT can effectively reduce the plasma levels of TNF-α , CRP and Increase the plasma levels of adiponectin in SAP patients, it play a therapeutic effect through changing the cytokine of SAP patients.