冠心病患者动脉弹性与血清高敏C反应蛋白和基质金属蛋白酶9的相关性

Association of Arterial Elasticity with Serum High Sensitivity C-reactive Protein and Matrix Metalloproteinase-9 in Patients with Coronary Heart Disease

目的探讨冠心病患者动脉弹性与高敏C反应蛋白和基质金属蛋白酶9的关系。方法运用动脉弹性功能测定仪检测大动脉弹性指数(C1)和小动脉弹性指数(C2);采用双抗体夹心ABC-ELISA法检测血清高敏C反应蛋白及基质金属蛋白酶9。结果 C1、C2、基质金属蛋白酶9及高敏C反应蛋白在冠心病组与对照组之间存在差异,且有统计学意义。Logistic逐步回归分析显示:男性、吸烟、低密度脂蛋白、C2、高血压史、高敏C反应蛋白是冠心病的独立危险因素。冠心病患者C1与高敏C反应蛋白及基质金属蛋白酶9相关系数分别为-0.51(P<0.01)和-0.49(P<0.01);C2与高敏C反应蛋白及基质金属蛋白酶9相关系数分别为-0.69(P<0.01)和-0.55(P<0.01)。冠心病患者动脉弹性影响因素多元逐步回归分析显示,C1独立影响因素为年龄、脉压、收缩压、高敏C反应蛋白、低密度脂蛋白、基质金属蛋白酶9,C2独立影响因素为年龄、脉压、空腹血糖、高敏C反应蛋白、低密度脂蛋白。结论冠心病患者动脉弹性与血清炎症因子高敏C反应蛋白及基质金属蛋白酶9均呈明显负相关,炎症反应可能是冠心病患者动脉弹性的重要影响因素之一。

Aim To explore the correlation between arterial elasticity indexes and serum high sensitivity C-reac- tive protein （hs-CRP） and matrix metalloproteinase-9 （MMP-9） in patients with coronary heart disease. Methods Large arterial elasticity index （ C1 ） and small arterial elasticity index （C2） were measured with CVProfilor DO-2020. Se- rum hs-CRP and MMP-9 were measured with ABC-double-antibody sandwich ELISA. Results There was significant difference between coronary heart disease group and control group in C1, C2, MMP-9 and hs-CRP. Logistic regression a- nalysis showed that male, smoking, low density lipoprotein cholesterol, C2, history of hypertension, hs-CRP were inde- pendent risk factors for coronary heart disease. Significant inverse correlation was noted between C1 and hs-CRP （ r = -0.51）, MMP-9 （r= -0.49）, and betweenC2 andhs-CRP （r= -0.69）, MMP-9 （r= -0.55） （allP〈0.01） in patients with coronary heart disease. Multiple linear regression analysis showed that independent risk factors for C1 in- cluded age, pulse pressure, systolic blood pressure, hs-CRP, low density lipoprotein cholesterol and MMP-9, and inde- pendent risk factors for C2 were age, pulse pressure, fasting blood sugar, hs-CRP and low density lipoprotein cholesterol in patients with coronary heart disease. Conclusions The present study showed that there was significantly negative cor- relation between arterial elasticity indexes and serum MMP-9 and hs-CRP in patients with coronary heart disease. The in