摘要
目的:观察胃癌组织c-Jun氮末端激酶(JNK)和血管内皮生长因子-C(VEGF-C)表达,分析其与临床病理学指标之间的关系及两者的相关性。方法:采用免疫组化SP法检测41例胃癌组织和10例正常胃组织JNK和VEGF-C的表达。结果:JNK在41例胃癌组织的阳性表达率为78.0%,在10例正常胃组织的阳性表达率为30.0%,两者比较差异有统计学意义,P<0.05。VEGF-C在胃癌组织的阳性表达率为80.5%,在正常胃组织的阳性表达率为10.0%,两者比较差异有统计学意义,P<0.05。JNK的阳性表达与胃癌是否有淋巴结转移及肿瘤大小相关,P值均<0.05。VEGF-C与胃癌是否有淋巴结转移及胃癌早晚分期相关,P值均<0.05。JNK和VEGF-C在胃癌组织中的表达具有一定相关性,r=0.457,P<0.01。结论:JNK可以用来评价胃癌淋巴结转移与肿瘤的大小,VEGF-C表达可评估胃癌组织的分期和淋巴结转移。联合检测胃癌组织中JNK和VEGF-C的表达可作为其评估预后的指标。
OBJECTIVE: To observe the expressions and correlation of c-Jun N-terminal kinase (JNK)and vascular endothelial growth factor C(VEGF-C) in gastric carcinoma tissues. METHODS: SP immunhistochemical stain was used to test the expressions of JNK and VEGF-C. The difference of JNK and VEGF-C expression among different indexs of pathologic factors was analyzed. RESULTS: The expression levels of JNK (78.0 %) and VEGF-C (80.5 %) were significantly higher in gastric carcinoma than those in normal gastric tissue (30.0% and 10.0%, P(0.05). In gastric carcinoma with lymph node metastasis the positive rates of JNK and VEGF-C were much higher than that in gastric carcinoma without metastasis (P〈0.05). The expression positive rate of VEGF-C was higher in advanced gastric carcinoma than that in early gastric cancer tissues (P〈O. 05). The expression positive rate of JNK was closely related to the tumor size (P〈0.05). There was significant positive correlation between the expression of JNK and VEGF-C in gastric carcinoma (r= 0. 457, P〈0. 01). CONCLUSIONS: JNK and VEGF-C are concerned with gastric carcinoma lymphatic metastasis. VEGF-C and JNK may be a good marker to monitor the lymphatic metastatic of gastric carcinoma.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第14期1082-1085,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
黑龙江卫生厅课题(No.2010-231)
关键词
胃肿瘤
病理学
信号通路
血管内皮生长因子-C
gastric neoplasms/pathology
signaling pathways
vascular endothelial growth factor C