福州市健康体检成人高尿酸血症发生率调查及相关危险因素分析

The incidence of hyperuricemia in healthy adults in Fuzhou city and the analysis of related risk factors

目的调查分析福州市健康成人高尿酸血症发生率及相关危险因素。方法收集2008-11-2009-08期间福建医科大学附属第一医院体检中心≥20岁的人群体检资料,回顾性分析该人群高尿酸血症的发生率,运用单因素及多因素Logistic回归分析高尿酸血症发生率和血尿酸水平与性别、年龄、体质量指数(BMI)、收缩压、舒张压、血肌酐、尿素氮、空腹血糖、三酰甘油、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等相关危险因素之间的关系。结果在资料完整的9581名体检者中,经年龄标化后高尿酸血症发生率为20.31%,其中男性高尿酸血症发生率为28.53%;女性高尿酸血症的发生率为9.68%。多因素Logistic回归分析结果显示,男性、肥胖、估算的肾小球滤过率(eGFR)降低、高血压和高三酰甘油血症是高尿酸血症的独立危险因素(OR值分别为0.349,1.692,11.745,1.259,2.153;均P<0.01)。随着代谢综合征组分数的增多,男女性人群的血尿酸水平也随之增高。结论福州市健康体检人群中高尿酸血症发生率为20.31%,男性、肥胖、eGFR降低、高血压和高三酰甘油血症是高尿酸血症的独立危险因素。

Objective To investigate the incidence of hyperuricemia in healthy adults and its related risk factors in Fuzhou. Methods The subjects who were ≥20 year-old and received physical examination at our hospital from November 2008 to August 2009 were enrolled. Following information were recorded, gender, age, body mass index （ BMI）, systolic blood pressure, diastolic blood pressure, serum creatinine, blood urea nitrogen, fasting blood glucose, uric acid, triglycerides, total cholesterol, high density lipoprotein-cholesterol （HDL-C） and low-density lip- oprotein-cholesterol （LDL-C）. The incidence of hyperuricemia was calculated. Univariate and multivariate logistic regression analyses were used to determine the relationship between hyperuricemia and related risk factors. Results After adjusted with age, the incidence of hyperuricemia was 20.31% in the enrolled 9581 healthy subjects with 28.53% in men and 9.68% in women respectively. Multivariate logistic regression analysis revealed that male, obesity, lower eGFR, hypertension and hypertriglyceridemia were independently associated with hyperuricemia （OR O. 349, 1. 692, 11. 745, 1. 259, 2. 153, respectively;all P^0.01）. With the increment of the components of metabolic syndrome, the incidence of hyperuricemia was increased. Conclusion The incidence of hyperuricemia was 20.31% in our studied healthy subjects. Mate, obesity, lower eGFR, hypertension and hypertriglyceridemia were independent risk factors for hyperuricemia.