银屑病中调节性T细胞的研究进展

Regulatory T cells in psoriasis

调节性T细胞是一类具有免疫调节功能的细胞群，对于维持机体免疫耐受和免疫应答稳态具有非常重要的作用。银屑病是多基因遗传背景下T细胞介导的免疫性疾病，其确切发病机制仍未阐明。在不同病期银屑病患者的皮损和外周血中，调节性T细胞的数量有显著差异，且有功能的改变。治疗后，随着临床症状的好转和PASI评分的下降，外周血中调节性T细胞的比例上升，抑制效应性T细胞的功能增强。调节性T细胞参与银屑病的发生和发展。

Regulatory T （Treg） cells, a group of cells with immunomodulatory effects, play essential roles in the maintenance of immune tolerance and immune homeostasis. Psoriasis is a T cell-mediated autoimmune disease with polygenetic background. The exact pathogenesis of psoriasis remains unclear. The number and function of Treg cells in peripheral blood and skin lesions varies with the stages of psoriasis. After treatment, with the improvement of clinical symptoms and decrease in psoriasis area and severity index （PASI） score, the percentage of Treg cells is elevated with an enhanced suppression on effector T lymphocytes. Treg cells may be involved in the initiation and progression of psoriasis.