组蛋白去乙酰化酶3在食管鳞状细胞癌发病机制中的作用
摘要
肿瘤细胞中组蛋白去乙酰化酶（histonedeacetylases，HDAC）的功能异常可抑制许多基因的转录，抑制抑癌基因的表达，在染色质重塑、基因阻遏、调节细胞周期和分化中发挥重要作用。HDAC共分为Ⅰ～Ⅳ类，HDAC3属于I类HDACE。目前I类HDAC已被证实在多种肿瘤中广泛表达。本研究采用荧光定量PCR及Western印迹法检测食管鳞状细胞癌组织中HDAC3的表达情况，
出处
《中华消化杂志》
CAS
CSCD
北大核心
2012年第11期760-762,共3页
Chinese Journal of Digestion
基金
江苏省镇江市社会发展科技支撑项目（SH2009012）
参考文献4
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1Mutze K, Langer R, Becker K, et al. Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer. Ann Surg Oncol, 2010,17 : 3336-3343.
-
2Bhaskara S, Knutson SK, Jiang G, et al. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell, 2010,18:436-447.
-
3Hayashi A, Horiuchi A, Kikuchi N, et al. Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin. Int J Cancer, 2010,127 : 1332-1346.
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4Minamiya Y, Ono T, Saito H, et al. Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocareinoma of the lung. Tumour Biol, 2010,31:533-539.
