食管间质瘤的临床分析及外科治疗

Clinical analysis and surgical treatment of 14 cases of esophageal gastrointestinal stromal tumors

目的探讨食管间质瘤的临床特点及外科治疗。方法回顾性分析中国医学科学院肿瘤医院自1999年1月至2012年4月治疗的经手术病理证实的14例食管间质瘤病例的临床资料。结果14例食管间质瘤患者男女比例为8：6；年龄33—63岁，中位年龄42岁。主要症状为吞咽困难，所有病例行肿瘤摘除术、食管部分切除术或内镜黏膜下切除术，均经术后病理确诊。中位随访时间为43．5个月，自2个月至142个月，无复发转移病例。结论食管间质瘤是一种罕见的间叶源性肿瘤，手术治疗为主要治疗手段，早期病例可获得满意治疗效果。

Objective To explore the clinical features and surgical management of esophageal gastrointestinal stromal tumors （GIST）. Methods The clinical data of patients with esophageal GISTs undergoing surgery at our hospital between January 1999 and April 2012 were retrospectively reviewed. Results Of 14 patients, the male： female ratio was 8：6 ; the median age of the patients was 42 years （range 33 -63 years ）. Dysphagia was the most common symptom, and all cases were diagnosed postoperatively. The tumors were resected by enucleation or esophagectomy or endoscopic submucosal resection. The median follow-up was 43.5 months, ranging from 2 to 142 months, with all patients have no recurrence and metastasis. Conclusion Esophageal GIST is rather rare. At present, surgical resection and postoperative diagnosis remain the mainstay for treatment of patients with esophageal GISTs in China.