核苷类抗肿瘤药物研究进展

Recent progress in research and development of nucleoside analogues as anticancer agents

核苷类似物为一类重要的抗肿瘤药物,占据抗癌市场近五分之一份额。本文根据药物化学结构和药理机制进行分类,在介绍已上市药物的基础上,对目前国际上新型抗癌药物、有应用前景的相关核苷类似物进行分类综述。重点关注近年来核苷类抗肿瘤药物的最新研究进展,各种前沿药物的作用机制及特点,同时简介未上市的核苷类抗癌药物的相关信息。

As an important type of anticancer drugs,nucleoside analogues have nearly one fifth the market share of anticancer.In this article,we classified drugs according to the chemical structures and pharmacological mechanisms.Based on the introduction of marketed drugs,current new anticancer drugs and nucleoside analogues which have good prospects were reviewed respectively.The molecular mechanisms and the characteristics of these nucleosides are addressed with focus on the recent development progress of nucleoside analogues as anticancer agents,and the highlights are the information of unlisted new anticancer agents.