红景天苷及其苷元酪醇的心血管保护作用

Cardiovascular protection effect of salidroside and its aglycone tyrosol

本文综述了红景天苷及其苷元酪醇对心血管的主要保护作用:①抗氧化作用,促进一氧化氮合成和抑制炎症介质前列腺素合成。②激活PI3K/Akt信号转导通路,上调缺氧诱导因子-1和血管内皮生长因子表达及Bcl-2/Bax比值。③抑制线粒体通透性转换孔开放,维护线粒体跨膜电位,阻滞半胱天冬酶-3激活,保护心肌细胞和血管内皮细胞。红景天苷和酪醇对抗缺血、缺氧、缺血再灌注或氧化应激引起的心血管细胞损伤,抑制氧化修饰的低密度脂蛋白形成、血管平滑肌细胞增殖和血小板聚集,降低血液粘度等,阻碍动脉粥样硬化发生和发展,产生心血管保护作用。

Salidroside and its aglycone tyrosol can protect cardiomyocytes and vascular endothelial cells by： ① antioxidation,promoting NO synthesis and inhibiting inflammatory mediator prostaglandin synthesis;② activating the PI3K/Akt signaling pathway,up-regulating the expressions of hypoxia-inducible factor-1 and vascular endothelial growth factor and Bcl-2/Bax ratio;③ inhibiting the open of mitochondrial permeability transition pore,maitaining mitochondrial transmembrane potential,and blocking the activation of caspase-3.Salidroide and tyrosol antagonize cardiovascular cells injury induced by ischemia,hypoxia,ischemia/reperfusion or oxidative stress,inhibit the formation of oxidized low-density lipoprotein（oxLDL） and proliferation of vascular smooth cells and platelet aggregation,decrease blood viscosity,hinder the occurrence and development of atherosclerosis,and induce cardiovascular protection.