丹参注射液对胃癌术后患者血液高凝状态的影响

Effect of Salvia injection on hypercoagulability of patients after operation for gastric carcinoma

目的:观察丹参注射液对胃癌术后患者血液高凝状态的影响。方法:选择行胃癌根治术后患者60例,随机分为对照组(C组)和丹参组(D组),每组30例。对照组采用常规化疗;丹参组在常规化疗的基础上,加用丹参注射液治疗。于化疗前后取外周血检测患者凝血功能,采用血栓弹力描记仪分析凝血状态的变化,彩色多普勒超声诊断深静脉血栓形成(deep venous thrombosis,DVT)。结果:与化疗前比较,D组患者化疗后的凝血功能明显改善(P<0.05),凝血指数明显下降(P<0.05),差异有统计学意义。与C组化疗后比较,D组化疗后的凝血功能和凝血指数明显改善(P<0.05),差异有统计学意义。化疗后,D组有3例(10%)患者发生DVT,而C组有12例(40%)患者发生DVT(P<0.05)。结论:丹参注射液能够改善胃癌术后患者血液高凝状态并减少DVT的发生。

Objective： To observe the effect of salvia injection on hypercoagulability of patients after operation for gastric carcinoma.Methods： A total of 60 postoperative patients were randomly divided into control group and Salvia group（n=30 in each group）.The control group received conventional chemotherapy,while Salvia group was given Salvia injection plus conventional chemotherapy.Blood clotting function was monitored before and after the chemotherapy,while the coagulation function of the patients was assessed by thrombelastography（TEG） analyzer,and DVT was diagnosed by color Doppler ultrasonic system.Results： The blood clotting function of the patients in Salvia group was obviously improved and coagulation index（CI） was obviously descend（P〈0.05）.The blood clotting function and CI of the patients in Salvia group were obviously improved in comparison with control group.DVT occurred in three patients（10%） in Salvia group and twelve（40%） patients in control group（P〈0.05）.Conclusion： Salvia injection can alleviate the hypercoagulability of gastric carcinoma patients during perioperative period and decrease incidence of DVT.