有创-无创序贯机械通气联合雾化吸入治疗严重呼吸衰竭临床研究

Efficacy observation of invasive-non-invasive mechanical ventilation sequential therapy combined with aerosol inhalation in severe respiratory failure

目的:探讨有创-无创机械通气序贯疗法联合雾化吸入治疗严重呼吸衰竭的临床疗效。方法:采用随机抽样的方式将患者分为观察组和对照组,两组患者给予不同的治疗。观察两组患者有创通气时间、呼吸机相关肺炎(VAP)发病率等指标。结果:观察组与对照组发生VAP例数分别为3例(9.6%)和15例(51.7%),总机械通气时间分别为(12.9±2.8)d和(18.6±3.5)d,住院时间分别为(16.3±3.7)d和(25.3±3.8)d,两组各项指标比较差异均有统计学意义(P<0.05)。结论:在肺部感染控制(PIC)窗指导下的有创-无创序贯通气治疗,能够显著减少机械通气时间,降低VAP发生,提高了抢救成功率。

Objective：To study the clinical effects of sequential non-invasive following short-term invasive mechanical ventilation on patients with severe respiratory failure.Methods：The study was divided into observation group and the control group.The patients from the two groups were given different treatment after pulmonary infection had been controlled.The invasive ventilation time,incidence of ventilator-associated pneumonia（VAP）and other items were recorded.Results：For observation group and the control group,the incidence of VAP was 9.6%（3 case） and51.7%（15 case） respectively,the total duration of mechanical ventilation was（12.9 ±2.8） d and（18.6±3.5） d respectively.The duration of hospitalization was（16.3±3.7） d and（25.3±3.8） d,respectively.Each index of two groups were significant difference（P〈0.05）.Conclusion：Sequential non-invasive following short-term invasive mechanical ventilation at the time of pulmonary infection control（PIC） window may significantly shorten the duration of mechanical ventilation and hospitalization,reduce treatment costs and the incidence of VAP,and enhance the rescue success rate.