β淀粉样蛋白的研究进展

Research Progress of Amyloid-β

阿尔茨海默病是老年人中最常见的一种痴呆症,其组织病理学表现主要为老年斑、神经元纤维缠结以及由凋亡引起的区域性神经细胞死亡等。患者脑内老年斑主要是由具有神经毒性和血管毒性的β淀粉样蛋白生成。β淀粉样蛋白可由多种细胞产生,因此β淀粉样蛋白是否可以作为除阿尔茨海默病以外的以血管增生为特点的疾病诊断指标目前尚无报道。

Alzheimer disease is the most common form of dementia in aged population.The major pathological findings of Alzheimer disease include senile plaques,neurofibrillary tangles,and apoptosis-related regional synaptic and neuronal degeneration.The brain senile plaques are mainly produced by amyloid-β,a peptide with neurotoxicity and vasculotoxicity.Amyloid-β can be produced by sorts of cells,therefore it′s assumed that if amyloid-β can be an index to diagnose other diseases related to angiogenesis except AD,which still remains to be reported up to now.