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E-钙粘蛋白在口腔鳞状细胞癌中的表达及意义 被引量:1

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摘要 目的观察E-钙粘蛋白在口腔鳞状细胞癌中的表达。方法运用SP免疫组织化学法进行试验,检测E-钙粘蛋白在口腔鳞状细胞癌中的表达及与口腔鳞状细胞癌组织学分级的关系。结果 E-钙粘蛋白在正常黏膜与口腔鳞癌中的表达差异有统计学意义(P<0.05),且其表达均与鳞癌的组织学分级具有相关性(P<0.05)。结论 E-钙粘蛋白的异常表达在口腔鳞状细胞癌的发生发展中起一定作用。
出处 《河北医药》 CAS 2012年第13期1942-1943,共2页 Hebei Medical Journal
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参考文献8

  • 1Morin PJ. Beta-catenin signaling and cancer. Bioesays, 1999,21:1021- 1030.
  • 2刘健,浦剑虹,葛自力,朱丽.E-cad、CD44V6在口腔鳞癌组织中的表达及其相关性研究[J].实用口腔医学杂志,2005,21(1):67-70. 被引量:7
  • 3李纾,刘琳,潘克清,葛少华,杨丕山.E-钙黏蛋白在出生后小鼠牙齿发育中的表达和意义[J].牙体牙髓牙周病学杂志,2004,14(12):670-673. 被引量:2
  • 4Stockinger A, Eger A, Wolf J. E-cadherin regulates cell growth by modu- lating proliferation-dependent beta-catenin transeriotional activity. J Cell Biol,2001,154 : 1185-1196.
  • 5唐瞻贵,邹萍,谢晓莉,姚志刚,蒋海鹰.E-cadherin基因蛋白在口腔疣状癌中的表达[J].湖南医科大学学报,2003,28(3):206-208. 被引量:5
  • 6Yamada K,Jordan R, Moil M, et al. The relationship between E-cadherin expression,clinical stage and tumor differentiation in oral squamous cell carcinoma. Oral Dis. 1997.3 : 82-85.
  • 7Chow V, Yuen AP, Lam KY, et al. Acomparative study of the clinicopath- ological significance of E-cadherin and catenins expression in the surgical management of oral tongue carcnoma. J Cancer Res Clinoneol, 2001, 127:59-63.
  • 8Yokoyama K, Kamata N, Hayashi E, et al. Reverse correlation of E-cad- herin and snail express in oral squamous cell careinoma ceils in vitro. O- ral Oncol,2001,37:65-71.

二级参考文献29

  • 1唐瞻贵,谢晓莉,粟红兵,施启迈,徐锡萍.口腔粘膜疣状癌电镜观察及其与临床病理的联系[J].湖南医科大学学报,1996,21(3):262-264. 被引量:11
  • 2李宏,Martin Hofmann,刘佳,江岩,郭丽,罗阳,鲁海欧.CD44v对大鼠多形胶质瘤细胞系RG2的转移促进作用[J].中华肿瘤杂志,1996,18(5):343-346. 被引量:11
  • 3Sakurai K, Urade M, Takahashi Y, et al. Increased expression of c-erbB-3 protein and proliferating cell nuclear antigen during development of verrucous carcinoma of the oral mucosa [ J ]. Cancer, 2000,89:2597-2605.
  • 4Koch BB, Trask DK, Hoffmam HT, et al. National survey of head and neck verrucous carcinoma[J]. Cancer. 2001.92:110-120.
  • 5Shiozaki H , Oka H, Inone M, et al. E-cadherin mediated adhesion system in cancer cell [ J ]. Cancer Supplement, 1996,77 :1605-1613.
  • 6Doki Y, Shiozaki H. Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line[ J]. Cancer Research , 1993,53:3421-3426.
  • 7Shiozaki H, Tahara H, Oka H, et al. Expression of immunoreactire E-cadherin adhesion molecules in human cancers [ J ]. Am J Pathol , 1991,139 : 17-23.
  • 8Tamura G, Yin J, Wang S,et al. E-cadherin gene promoter hypennethylation in primary human gastric carcinomas [ J ]. J Nail Cancer Inst ,2000,92:569-573.
  • 9Cheng HW,Chow V, Lam KY,et al. Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance [ J ]. Cancer, 2002,94 :386-392.
  • 10Humphrey PA, Wong AJ,Vogelstein B, et al.Amplification and expression of EGFR in human glioma xenografts. Cancer Res,1988,48(8):2231.

共引文献11

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  • 1胡蕾,姜汉国.PI3K/AKT信号转导通路与肿瘤转移及其机制的研究进展[J].医学综述,2006,12(22):1375-1377. 被引量:18
  • 2Irie H Y, Pearline R V, Grueneberg D, et al.Distinct roles of Aktl andAkt2 in regulating cell migration and epithelial-mesenchymal transition[J].Cell Biol, 2005, 171(14): 1023-1034.
  • 3Theresa Vincent, Etienne P A Neve, Jill R Johnson, et al.A SNAIL1/SMAD3 or 4 transcriptional repressor complex promotes TGF-betamediated epithelial-mesenchymal transition[J].Nature Cell Biology,2009, 21(8): 943-950.
  • 4Theys J, Jutten B, Hahets R, et al. E-Cadherin loss associated withEMT promotes radioresistance in human tumor cells[J].Radiotherapy andOncology, 2011,99(14): 392-397.
  • 5Jean Paul Thiery.Epithelial-mesenchymal transitions in development anddisease[J]. Cell, 2009, 139(41): 871-890.
  • 6Eduard Batlle.The transcription factor snail is a repressor of E~cadheringene expression in epithelial tumor cells[J].Nature Cell Biology, 2000,12(1): 84-89.
  • 7Grille S J, Bellacosa A, Upson J, et al. The protein kinase Akt inducesepithelialmesenchymal transition and promotes enhanced motility andinvasiveness ofsquamous cell carcinoma lines[J].Cancer Res, 2003,63(14): 2172-2178.
  • 8Luika A.Notch promotes epithelial-mesenchymal transition during cardiacdevelopment and oncogenic transformation[J].Genes Dev, 2004,18(9):99-115.
  • 9E H Gort. The TWIST1 oncogene is a direct target[J].Oncogene, 2008,27(16): 1501-1510.
  • 10Monique M.Expression of E-cadherin and vimentin correlates withmetastasis formation in head and neck squamous cell carcinomapatients[J]. Radiotherapy and Oncology, 2011,99(24): 344-348.

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