1Colombo ML, Bugatti C, Mossa A, et al. Cytotoxicity evaluation of natureal cop tisine and synthesis of cop tisine from Berberine. Farmaco,2001,56: 403.409.
2Orfila L, Rodriguez M, Colman T, et al. Structuralmodification of berber- ine alkaloids in relation to cytotoxic activity in vitro. J Ethnopharmacol, 2000,71:449-456.
3Iizuka N, Miyamoto K, Okita K, et al. Inhibitory effect of cop tidis rhizoma and berbefine on the proliferation of human esophageal cancer cell lines. CancerLett,2000,148 : 19-25.
4Kizaki H, Onishi Y. Topoisomerase H Inhibitor Induced apoptosis in thy- mocytes and lymphoma cells. Adv Enzyme Regul,1997 ,37 :403-423.
5Lee KH. Anticancer drug design based on plant derived natural products. J Biomed Sci, 1999,6:236-250.
2Kuo CL, Chou CC, Yung BY. Berberine complexes with DNA in the berberine-induced apoptosis in the human leukemic HL-60 cells. Cancer Lett,1995;93(2)∶193～200.
3Chang KS. Down-regulation of c-ki-ras2 gene expression associated with morphologic differentiation in human embryonal carcinoma cells treated with berberine. J Formos Med Assoc,1991;90(1)∶10～14.
4Chi CW, Chang YF, Chao TW, et, al. Floweycyometric analysis of the effect of berberine on the expression of glucocorticoid recptors in human hepatoma HepG2 cells. Lfe Sci,1994;54(26)∶2099～2107.
5Kizaki H, Onishi Y. Topoisomerase Ⅱ Inhibitor-Induced apoptosis in thymocytes and lymphoma cells. Adv Enzyme Regul,1997;37∶403～423.
6Lee KH. Anticancer drug design based on plant-derived natural products. J Biomed Sci,1999;6(4)∶236～250.
7Lee, FD. Importance of apoptosis in the histopathology of drug related lesions in the large Intestine. J Clin Pathol,1993;46(2)∶118～122.
8Jiang S, Song MJ, Shin EC, et al. Apoptosis in human hepatoma cell lines by chemotherapeutic drugs via Fas-dependent and Fas-independent pathways. Hepatology,1999;29(1)∶101～110.
9Hockenbery D. Defining apoptosis. Am J Pathol,1995;146(1)∶16～19.
10Ansari B, Coates PJ, Greenstein BD, et al. In situ end labeling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol,1993;170(1)∶1～8.
