蛛网膜囊肿的临床病理诊断特征

Clinicopathologic characteristics of arachnoid cyst

目的探讨蛛网膜囊肿的临床病理特点、诊断及鉴别诊断。方法采用HE染色法和免疫组织化学染色法,观察7例蛛网膜囊肿的组织学特征和免疫表型,结合临床资料和文献进行分析。结果组织学特征为囊壁内衬上皮为单层扁平上皮、部分区域上皮增生,囊肿内横贯小梁缺失,囊壁纤维组织增生。免疫组织化学检测显示囊壁内衬上皮EMA或CK呈阳性表达,S-100、GFAP、CD34、CD31和FVIII均为阴性。结论蛛网膜囊肿是颅内罕见的囊性占位病变,是上皮源性囊肿,病理诊断易误诊为血管源性囊肿或神经源性囊肿,其诊断主要依靠影像学、病理组织学特点和免疫组织化学标记。

Objective To study the clinic pathological features,diagnosis and differential diagnosis of arachnoid cysts.Methods The histological features and immunophenotypes of seven cases of arachnoid cyst were observed by HE staining and immunohistochemistry with the help of clinic datas and references.Results Histological features showed that the lining epithelial cells of the cyst were composed by simple squamous epithelial cells with some areas hyperplasia.The trabeculars across the cyst were missed and the cyst wall was fibrosis.Immunohistochemical analysis showed that the expressions of EMA and CK in majority of epithelial cells were positive while S-100,GFAP,CD34,CD31 and FVIII were negative.Conclusions Arachnoid cyst is a rare intracranial cystic occupying lesion which is derived from epithelial.The arachnoid cyst is always been misdiagnosed as vascular or neurogenic cyst by Pathological diagnosis which diagnosed mainly depends on imaging,histopathological features and the immunohistochemical markers.