2,5-二甲基-N-吡咯乙酸芳樟酯的合成及其卷烟加香应用研究

Synthesis of 2,5-Dimethyl-N-Pyrrole Linalyl Ester and its Application in Unblended Cigarette

以2,5-己二酮和甘氨酸为原料,以冰醋酸为催化剂,通过Pall-Knorr反应生成2,5-二甲基-N-吡咯乙酸,然后在EDC的缩合作用下与芳樟醇反应生成2,5-二甲基-N-吡咯乙酸芳樟酯。通过1H NMR、13C NMR、IR、HRMS等方法对产物的结构进行验证。并对产物进行热重分析以及热裂解行为研究,分析鉴定出了50多种裂解产物,其多数为致香物质。对目标物进行卷烟加香评吸,结果表明该物质能改善卷烟吸味,减轻卷烟吸食刺激性,增强香气。

Using 2,5-hexanedione and glycine as raw material and acetic Acid as catalyst, 2,5-dimethyl-N-Pyrrole glycine was synthesized by Pall-Knorr reaction and then reacted with Linalool, giving 2,5-dimethyl-N-pyrrole linalyl ester was synthesized under the dehydration of EDC. The structures of the compounds were confirmed by IR, 1H NMR, 13C NMR and HR MS spectral analysis. Then the applications of the ester in cigarette flavoring were studied. More than 50 kinds of pyrolysis products were authenticated. Most of the pyrolysis products were aroma components. The smoke panel test showed that the new compound could improve the cigarette taste and flavor, reduce smoking irritation of cigarette.