沈阳地区中青年脂肪肝患病情况与危险因素分析

Relationship between fatty liver and risk factors of young and middle-aged population in Shenyang

目的了解沈阳地区中青年人群脂肪肝的患病情况,并分析其与体质量指数(BMI)、腰臀比(WRI)、血压、血脂之间的相关性。方法收集沈阳地区9 556名中青年体检者的临床资料,计算各年龄段脂肪肝的患病率;并按有无脂肪肝分为脂肪肝组和非脂肪肝组,比较2组BMI、WRI、血压、甘油三酯(TG)、胆固醇(CHOL)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的差异;并对脂肪肝的危险因素进行分析。结果①人群脂肪肝患病率为36.4%,其中男性患病率为46.2%,女性患病率为24.8%,两者比较差异有统计学意义(P<0.01)。②各年龄段内脂肪肝组BMI,WRI,收缩压(DBP),舒张压(SBP),TG,CHOL,LDL-C均高于非脂肪肝组;而脂肪肝组HDL-C低于非脂肪肝组(P均<0.01)。③脂肪肝与BMI、WRI、DBP、TG呈正相关(P均<0.01),而与HDL-C呈负相关(P<0.01)。结论①人群脂肪肝的男性患病率高于女性;②脂肪肝的患病率随年龄的增长呈升高的趋势;③BMI、WRI、血压增高、血TG是脂肪肝的危险因素,而高HDL-C是脂肪肝的保护因素。

Objective To explore the prevalence of the fatty liver,and to analyze its relationship with BMI,WRI,BP and lipids.Methods This cross-sectional study randomly included 9 556 young and middle-aged population in Shenyang.We calculated the prevalence of fatty liver of different age groups.According to the availability of fatty liver,they were divided into fatty liver and non-fatty liver groups,the difference of two groups were compared in BMI,WRI,BP,triglyceride（TG）,cholesterol（CHOL）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）.The relationship between fatty liver and its components of metabolic syndrome was analyzed.Results ①The prevalence of the fatty liver was 36.4%,46.2% in males and 24.8% in females and the difference was statistically significant between these two groups（P0.01）.②In every age group,the mean of BMI,WRI,DBP,SBP,TG,CHOL and LDL-C in fatty liver group was higher than that in non-fatty liver group,respectively.HDL-C in fatty liver group was lower than that in non-fatty liver group（P0.01）.③The fatty liver was positively correlated with BMI,WRI,DBP,TG（P0.01）,and negatively correlated with HDL-C（P0.01）.Conclusion ①The prevalence of fatty liver in males is higher than that in females.②The fatty liver is associated with metabolic syndrome and its components.BMI,WRI,TG and hypertension are risk factors of fatty liver,while HDL-C is a protective factor of fatty liver.