布地奈德混悬液和异丙托溴铵溶液雾化吸入治疗慢性阻塞性肺疾病急性加重期临床观察

Clinical observation on the effect of combination of budesonide and compomld ipratropium bromide aerosol used in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease

目的:观察布地奈德联合复方异丙托溴铵雾化吸入对慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:对70例AECOPD住院患者随机分为观察组和对照组各35例,观察组在常规治疗的基础上给予布地奈德和复方异丙托溴铵雾化吸入治疗,对照组在常规治疗基础上给予复方异丙托溴铵雾化吸入治疗,分析两组的临床疗效。结果:两组治疗前后呼吸困难评分、肺功能和血气分析等比较,差异有统计学意义(P<0.05)。结论:治疗后两组间各对应指标,差异有统计学意义(P<0.05)。结论:布地奈德联合复方异丙托溴铵雾化吸入对AECOPD能迅速缓解症状,畅通气道,改善肺功能,疗效优于单一用药,是治疗AECOPD的有效选择。

Objective To study the effect of budesonide combined with compomld ipratropium bromide aerosol in treatment of patients with acute exacerbation of chronic obstructive pulmonary disease.Method Seventy patients with AECOPD were randomly divided into observation group（35 cases） and control group（35 cases）.Patients in observation group were treated with conventional therapy of budesonide and compomld ipratropium bromide aerosol besides routine therapeutic regimen and patients in control group were treated with compomld ipratropium bromide aerosol.The clinical efficacy was compared and analyzed between patients of these two groups.Results The differences in dyspnea scores,lung function and blood gas analysis were compared before and after the treatment,and their difference had statistically significant（P0.05）.The difference in corresponding indicators between these two groups had statistically significant（P0.05）.Conclusion Budesonide and compomld ipratropium bromide aerosol can rapidly relieve symptoms of AECOPD,smooth airway and improve lung function,it is more effective than the application of single drug,and it is an effective choice for treatment of patients with AECOPD.