雷贝拉唑治疗非糜烂性反流病的疗效

Efficacy of rabeprazole in the treatment of non-erosive reflux disease

目的:观察探讨雷贝拉唑治疗非糜烂性反流病的临床疗效。方法:选取54例非糜烂性反流病的患者,随机分为观察组和对照组,各27例,观察组给予雷贝拉唑治疗,对照组给予雷尼替丁治疗,观察比较两组治疗效果。结果:治疗后2周对24 h食管下段的pH值进行监测,与治疗前比较差异有统计学意义(P<0.05)。结论:雷贝拉唑治疗非糜烂性反流病的临床疗效显著,优于雷尼替丁治疗,能够显著改善临床症状。

Objective To observe and investigate the clinical efficacy of rabeprazole in the treatment of non-erosive reflux disease.Method From March 2009 to March 2011,54 cases of non-erosive reflux disease patients were randomly divided into observation group and control group,each was 27 cases,the observation group were treated with rabeprazole and control group was treatmed with ranitidine,and compared the two groups of treatment.Results 2 weeks after treatment the 24h lower esophagus pH was monitored,there was significant difference（P0.05） compared with before treatment,statistically significant.Conclusion The clinical efficacy of rabeprazole in the treatment of non-erosive reflux disease is significantly superior to ranitidine therapy,and it can significantly improve the clinical symptoms.