消郁安神胶囊对慢性轻度不可预见应激大鼠抑郁模型的影响

Effect of Xiaoyuanshen capsule on depressive behavior of rats induced by chronic mild unpredic-table stress

目的:观察消郁安神胶囊对慢性轻度不可预见应激抑郁大鼠模型的影响。方法:以慢性轻度不可预见应激建立大鼠抑郁模型,灌胃给予消郁安神胶囊(3.3,10,30 mg.kg-1)和舍曲林(5 mg.kg-1)。通过旷场实验、强迫游泳实验测定大鼠行为学变化情况。生化酶学方法测定大鼠海马中超氧化物歧化酶(SOD)与丙二醛(MDA)的含量变化。结果:旷场实验结果显示慢性轻度不可预见应激抑郁大鼠在中央格停留时间明显延长、垂直运动次数明显减少;抑郁大鼠在强迫游泳实验中静止时间所占百分比明显超过正常组;抑郁大鼠海马MDA含量明显升高,SOD活性明显降低。消郁安神胶囊给予能剂量依赖性缩短抑郁大鼠在中央格停留时间、增加垂直运动次数,并能明显减少大鼠在强迫游泳实验中静止时间。消郁安神胶囊能明显下调抑郁大鼠海马MDA含量并提高SOD活性。结论:消郁安神胶囊能明显改善慢性轻度不可预见应激大鼠的抑郁行为,其机制可能与抗氧化应激、减少炎症反应有关。

OBJECTIVE To observe the effect of Xiaoyuanshen Capsule on depressive behavior of rats induced by chronic mild unpredictable stress. METHODS Depressive model of rats was established by chronic mild unpredictable stress depres- sion. Xiaoyuanshen capsule（3.3,10 and 30 mg·kg^-1 ） was through intragastric administration. The open-field test and force swimming test were used to evaluate the effect of Xiaoyuanshen capsule. SOD activity and MDA content of rat hippocampus were determined. RESULTS Compared with that of control group, crossing time obviously increased and the rearing time of rats significantly decreased in model group, and the duration of immobility of rats significantly increased. Administration of Xi- aoyuanshen capsule obviously improved the depressive behavior of rats induced by chronic mild unpredictable stress. Adminis- tration of Xiaoyuanshen capsule obviously decreased hippocampus MDA content, and increased SOD activity. CONCLUSION Xiaoyuanshen capsule has a potent clinical value to depression.