摘要
重组人脑利钠肽(rhBNP)具有扩张血管、利尿排钠、降低血浆醛固酮水平等药理作用。现已完成的VMAC、PRECEDENT等前瞻性临床试验初步揭示其治疗心力衰竭的有效性。然而,荟萃分析显示,rhBNP有可能导致。肾功能恶化和增加死亡率。
Recombinant human brain natriuretic peptide (rhBNP) is capable of dilating vessels, natriuresis and diuresis, and reducing plasma aldosterone level, etc. Many prospective clinical studies like VMAC and PRECEDENT reveal the effectiveness in treatment of heart failure. This article reviews rhBNP and its properties in the management of heart failure.
出处
《国际老年医学杂志》
2012年第6期274-277,共4页
International Journal of Geriatrics
关键词
重组人脑利钠肽
心力衰竭
治疗
Recombinant human brain natriuretic peptide
Congestive heart failure
Drug therapy