摘要
目的初步探讨帕利哌酮缓释片合并文拉法辛治疗难治性抑郁症(TRD)的疗效与安全性。方法 49例TRD患者随机分为研究组(帕利哌酮缓释片合并文拉法辛)和对照组(单用文拉法辛),疗程6周。治疗前及治疗后第1、2、4、6周分别采用汉密尔顿抑郁量表(HAMD)、临床疗效总评量表-病情严重程度(CGI-SI)和不良反应量表(TESS)评定疗效和不良反应。结果研究组有效率64%,对照组有效率33.33%,研究组有效率显著高于对照组(χ2=4.608,P<0.05)。治疗6周后,两组HAMD与CGI-SI评分比较差异有显著性(P<0.01),但组间TESS评分差异无显著性(P>0.05)。结论小剂量帕利哌酮缓释片在难治性抑郁症的治疗中有增效作用,优于单用文拉法辛,安全性较高,患者依从性好。
Objective To explore the efficacy and safety of paliperidone ER combined with venlafaxine for treating treatment resistant depression（TRD）.Methods A total of 49 TRD patients were randomly divided into study group（n=25,paliperidone ER combined with venlafaxine）and control group（n=24,venlafaxine monotherapy）with the course of 6 weeks.Hamilton Depression Scale（HAMD17）,Clinical Global Impression-Severity of Illness（CGI-SI）and Treatment Emergent Symptom Scale（TESS）were used to evaluate clinical efficacy and side effects before and at 1,2,4,6 weeks after the treatment.Results The overall effective rate of study group（64%）was significantly higher than that of control group（33.33%）（χ2=4.608,P0.05）.Between two groups at the 6th week after the treatment,there were significant differences of the scores of HAMD and CGI-SI（P0.01）,but no significant difference of the scores of TESS（P0.05）.There were no significant difference of the rate of adverse reaction between two groups（χ2=0.698,P0.05）.Conclusion Venlafaxine augmented with small dose paliperidone ER has better clinical efficacy than venlafaxine monotherapy in the treatment of treatment resistant depression with high safety and treatment compliance.
出处
《中国健康心理学杂志》
2012年第10期1453-1455,共3页
China Journal of Health Psychology
