摘要
目的比较盐酸文拉法辛缓释剂与阿米替林治疗广泛性焦虑症(GAD)的疗效与安全性。方法采用随机分组的方法将56例GAD患者分为盐酸文拉法辛组(28例)和阿米替林组(28例),治疗4周,在治疗前和治疗后1、2、4周分别进行汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果盐酸文拉法辛与阿米替林对GAD均有显著疗效,两组间无显著性差异。盐酸文拉法辛组不良反应明显小于阿米替林组。结论盐酸文拉法辛缓释剂治疗GAD安全有效,不良反应少。
Objective To compare the efficacy and safety of venlafaxine and amitriptyline in the treatment of GAD.Methods A total of 56 patients with GAD were randomly divided into venlafaxine group（n=28）and amitriptyline group（n=28）.They were treated for 4 weeks.The clinical efficacy and side effects were evaluated with HAMA and TESS before treatment and 1,2,4 weeks after treatment.Results There were significant efficacy in both venlafaxine group and amitriptyline group.The side effects in venlafaxine group were significant lower than those in amitriptyline group.Conclusion Venlafaxine shows efficacy and safety in the treatment of GAD with lower side effects.
出处
《中国健康心理学杂志》
2012年第10期1472-1473,共2页
China Journal of Health Psychology
