注射用头孢噻肟钠与奥硝唑氯化钠注射液配伍稳定性的实验研究

Experiment Research on Stability of Compatibility of Cefotaxime Sodium for Injection and Ornidazole Sodium Chloride Injection

目的:观察注射用头孢噻肟钠与奥硝唑氯化钠注射液配伍后的稳定性。方法:采用紫外分光光度法测定两药配伍后不同时间的含量及吸收曲线变化,每隔30分钟测定溶液的pH值,并观察外观变化。结果:头孢噻肟钠在236nm,奥硝唑在319nm处有最大吸收,混合吸收曲线未发生改变,也未见其他吸收曲线产生;混合液在1～1.5h时变为淡粉色,但无沉淀产生,含量、pH值均无明显变化。结论:头孢噻肟钠与奥硝唑氯化钠注射液配伍后可能会变色,临床应避免配伍使用。

Objective： To investigate stability of eompatility of ornidazole injection instilled after cefotaxime sodium for injection. Methods： The contents and absorption curves of cefotaxime sodium for injection and ornidazole sodium chloride injection after mix were determined by ultraviolet spectrophotometry. The solution pH was assayed every 30 minutes, and the appearance of mixture was observed. Results： The absorption peaks of cefotaxime sodium and omidazole sodium chloride were at 236 nm and 319 nm, respectively. The mix- tures turned into pale pink from 1 hour to 1.5 hour after mix, but there were no evident changes in appearance, pH, content and absorp- tion curves during 4 hours. Conclusion： Ornidazole injection compatibility and eefotaxime sodium for injection clinical should avoid cefo- taxime sodium and omidazole and sodium chloride injection compatibility to prevent discoloration.