甲钴胺致不良反应文献分析

Literature Analysis of Adverse Drug Reactions Induced by Mecobalamin

目的:探讨甲钴胺致不良反应的一般规律与特点。方法:检索CHKD期刊全文数据库及中华医学会期刊索引库,收集2002年1月至2012年6月甲钴胺所致不良反应文献,并进行统计、分析。结果:甲钴胺引起的不良反应共计12例,男性多于女性。所致不良反应最多为皮肤系统损害6例(50.00%),其次为心血管系统2例(16.67%)、全身性损害1例(8.33%)、呼吸系统障碍1例(8.33%)、女性生殖系统损害1例(8.33%)、中枢及外周神经系统1例(8.33%)。结论:临床上应加强甲钴胺应用的监测,以减少不良反应的发生。

Objective：To investigate the general characteristics of the adverse effects induced by mecobalamin. Methods： We searched the ＂China Journal Full-text Database＂ and ＂Chinese Scientific and Technical Periodicals Database＂ from January 2002 to June 2012 due to mecobalamin adverse drug reactions, and statistical analysis. Results： The adverse reactions of mecobalamin totalled in 12 cases and more men than women, adverse reactions caused maximum damage for the skin system in 6 cases （50. 00% ） , followed by the cardiovascular system in 2 cases （16.67%）, systemic damage in 1 case （8. 33% ）, respiratory system disorders （8.33%）, female re- productivesystem damage in 1 case （8.33 % ） , the central and peripheral nervous system in 1 case （8. 33% ）. Conclusion： The clinical application should strengthen monitoring of mecobalamin in order to reduce the incidence of adverse reactions.