缺血性卒中的基因组学研究进展

Advances in genolrdcs for ischaemic stroke

缺血性卒中是导致成年人残疾和死亡的主要疾病之一。年龄、性别、吸烟、高血压和糖尿病等是缺血性卒中的危险因素，但它们仅能部分解释卒中发病的原因。孪生子、家系以及单基因遗传性卒中研究显示，缺血性卒中具有明显的遗传倾向性。近年来，基因组学在缺血性卒中研究中取得了明显进展，并显示许多新的单核苷酸多态性或基因与缺血性卒中及其危险因素有关。然而，这些遗传基因对缺血性卒中的贡献仍然太小，需要重复性研究进一步证实。

Isehemie stroke is one of the major diseases of causing adult disability and death. Age, sex, smoking, hypertension, and diabetes, etc. are the risk factors for ischemic stroke, but they can only partially explain the reasons of stroke onset. Twins, families, and single-gene genetic stroke studies have shown that ischemic stroke has obvious genetic predisposition. In recent years, genomics has made remarkable progress in isehemic stroke study and has shown that many new single nueleotide polymorphisms or genes are associated with isehemic stroke and its risk factors. However, the contribution of these genetic genes for ischemie stroke is still too small and the repetitive studies are needed for further confimation.