甲亢患者骨代谢相关细胞因子及骨代谢指标的变化研究

Study on the changes of bone metabolism related cytokines and bone metabolic indexes of patients with hyperthyroidism

目的探讨甲亢患者骨代谢相关细胞因子及骨代谢指标的变化规律。方法选择2010年5月～2011年1月于本院进行治疗的64例甲亢患者为观察组,选择同期进行健康体检的64名人员为对照组。将两组患者的甲状腺激素、骨代谢相关细胞因子及骨代谢指标水平进行检测及比较。结果甲状腺相关激素:观察组游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、甲状腺旁素(PTH)水平均高于对照组,促甲状腺激素(TSH)水平低于对照组(P<0.05);骨代谢相关细胞因子:观察组白介素-6(IL-6)水平高于对照组,降钙素(CT)、肿瘤坏死因子(TNF)、胰岛素样生长因子-Ⅱ(IGF-Ⅱ)水平明显降低对照组(P<0.05);骨代谢指标:观察组钙离子(Ca2+)、碱性磷酸酶(AKP)、骨钙素(BGP)、Ⅰ型胶原吡啶交联终肽(ⅠCTP)及Ⅰ型原胶原氨基端前肽(PⅠNP)均高于对照组高,骨密度(BMD)低于对照组(P<0.05)。结论甲亢患者可表现出骨代谢相关细胞因子及骨代谢指标的明显变化,在此类患者的治疗过程中对此方面也应给予足够的重视。

Objective To study varying pattern of bone metabolism related cytokines and bone metabolic indexes of patients with hyperthyroidism.Methods 64 cases of patients with hyperthyroidism in our hospital from May 2010 to January 2011 were selected as the observation group,at the same time 64 healthy personnel were selected as the control group.The thyroid hormone,bone metabolism related cytokines and bone metabolic indexes between the two groups were detected and compared.Results Thyroid related hormones： FT4,FT3 and PTH of the observation group were all higher than those of the control group;TSH was lower than that of the control group（P 0.05）.Bone metabolism related cytokines： IL-6 of the observation group was higher than that of the control group;CT,TNF and IGF-Ⅱ were all significantly lower than those of the control group（P 0.05）.Bone metabolic indexes： Ca2＋,AKP,BGP,I CTP and P I NP of the observation group were all higher than those of the control group;BMD was lower than that of the control group（P 0.05）.Conclusion Changes of bone metabolism related cytokines and bone metabolic indexes of patients with hyperthyroidism are obvious,and it should be paid enough attention during treatment.