急性颅脑损伤患者高压氧治疗后超敏C反应蛋白水平变化及定量脑电图分析

Analysis of high sensitivity C-reactive protein levels and quantitative EEG after hyperbaric oxygen therapy on acute traumatic brain injury patients

目的观察高压氧治疗后急性颅脑损伤患者C反应蛋白水平变化及定量脑电图各指标的变化,进一步评价高压氧对急性颅脑损伤的治疗效果。方法 60例颅脑外伤患者随机分为高压氧治疗组(n=30)及对照组(n=30),对照组仅给予常规药物治疗,高压氧治疗组在常规药物治疗基础上给予高压氧治疗组。治疗前及治疗后30 d行定量脑电图检查、超敏C反应蛋白测定及神经功能缺损评分NIHSS。结果与治疗前相比,高压氧治疗组的超敏C反应蛋白降低,脑电图频段相对能量值增加,神经功能缺损评分有改善。治疗后两组的超敏C反应蛋白水平、脑电图频段相对功率值及神经功能缺损评分比较,差异有统计学意义(P<0.05)。结论早期高压氧治疗可降低急性颅脑损伤患者超敏C反应蛋白水平,改善脑功能,促进神经功能的恢复,具有疗效好、安全、无明显不良反应的优点。

Objective To observe the changes on C-reactive protein levels and quantitative EEG after hyperbaric oxygen therapy in acute traumatic brain injury patients and further to evaluate the effect of hyperbaric oxygen treatment for acute traumatic brain injury.Methods 60 patients with traumatic brain injury were randomly divided into hyperbaric oxygen treatment group（n = 30） and the control group（n = 30）.the control group only received conventional drug therapy and hyperbaric oxygen treatment group was given conventional drug treatment and hyperbaric oxygen therapy.Before and 30 days after the treatment,quantitative EEG,high sensitivity C reactive protein and neurological deficit score（NIHSS） were all made.Results In the hyperbaric oxygen treatment group,compared with those before treatment,the level of high sensitivity C-reactive protein decreased,EEG α bands relative energy values increased and neurological function was improved.Comparing the two groups after treatment,there were significant differences in the level of high sensitivity C-reactive protein,the qEEG bands relative power values and the neurological deficit scores（P 0.05）.Conclusion Early hyperbaric oxygen therapy can reduce the level of high sensitivity C-reactive protein and improve brain function and promote the recovery of neurological function in acute traumatic brain injury patients,which have good efficacy and safety and without no significant adverse reactions.