摘要
目的探讨血浆Apelin水平与2型糖尿病患者心功能的关系。方法本研究共纳入2型糖尿病患者114例(DM组)及非糖尿病对照者82例(对照组),使用酶联免疫吸附法(ELISA)测量两组血浆Apelin水平,采用超声心动图评价2型糖尿病患者的心脏收缩及舒张功能。结果 DM组患者血浆Apelin水平较对照组显著增高[(3.89±0.56)ng/mLvs(1.25±0.32)ng/mL,P<0.01)。在2型糖尿病患者中,随着纽约心脏病学会(NYHA)心功能分级的增加,血浆Apelin水平逐渐降低(P<0.05或P<0.01)。血浆Apelin水平与2型糖尿病患者的左室舒张末期内径(LVDD)呈负相关,与E/A比值呈显著正相关(均P<0.01)。结论 2型糖尿病患者血浆Apelin水平较健康对照者显著升高,在2型糖尿病患者中,血浆Apelin水平越低者心功能越差。Apelin有望成为预测2型糖尿病患者心功能的一个重要血浆生物学标记物。
Objective To discuss the association between plasma Apelin level and cardiac function in patients with type 2 diabetes.Methods 114 patients with type 2 diabetes（DM group） and 82 non-diabetes mellitus controls（control group） were included in this study.Plasma Apelin level was determined by enzyme-linked immunosorbent assay（ELISA） kit,systole and diastolic function of patients with type 2 diabetes were assessed by echocardiography.Results Plasma Apelin level in DM group was significantly higher than that in control group [（3.89±0.56） ng/mL vs（1.25±0.32） ng/mL,P 0.01].In patients with type 2 diabetes,plasma Apelin levels decreased with the increment of New York Heart Association（NYHA） cardiac functional classification（P 0.05 or P 0.01）.Plasma Apelin level was negatively associated with left ventricular end-diastolic dimension（LVDD） and positively associated with E/A ratio（all P 0.01） in patients with type 2 diabetes.Conclusion Compared with healthy controls,plasma Apelin levels increased in patients with type 2 diabetes.Plasma Apelin levels decreased with the deterioration of cardiac function in patients with type 2 diabetes.Apelin may be a potential plasma biomarker for reflecting cardiac function in patients with type 2 diabetes.
出处
《中国医药导报》
CAS
2012年第31期44-45,47,共3页
China Medical Herald
