冠状动脉介入治疗对冠心病患者血浆白细胞介素-6和肿瘤坏死因子α水平的影响

The effects of plasma interlekin-6 and tumor necrosis factor α on patients with coronary artery disease by percutaneous coronary interventional procedures

目的通过测定冠心病患者行冠状动脉介入治疗前后白细胞介素-6(IL-6)及肿瘤坏死因子α(TNF-α)血浆水平,分析冠状动脉支架术对冠心病患者炎症指标的影响。方法连续入选经冠状动脉介入治疗单支病变的冠心病患者70例为冠脉介入组,经冠状动脉造影证实冠状动脉正常者30例为对照组。采用酶联免疫吸附法检测入选患者冠状动脉介入治疗前后IL-6和TNF-α水平。结果冠脉介入组患者术后血浆IL-6为(21.49±4.45)pg/L,显著高于术前,差异有高度统计学意义(P<0.01);对照组冠状动脉造影术后IL-6为(13.07±4.12)pg/L,与术前比较差异无统计学意义(P>0.05)。冠脉介入组患者术后血浆TNF-α为(15.67±4.25)ng/mL,显著高于术前的(12.56±4.13)ng/mL,差异有高度统计学意义(P<0.01);对照组冠脉造影术后TNF-α为(11.23±3.87)ng/mL,与术前比较差异无统计学意义(P>0.05)。结论冠脉介入治疗促进冠心病患者血浆IL-6及TNF-α水平的升高,是否为冠脉介入治疗术后支架内再狭窄的重要机制之一尚待进一步考证。

Objective To explore the effect of interlekin-6（IL-6） and tumor necrosis factor α（TNF-α） following percutaneous coronary interventional procedures（PCI） in patients with coronary artery disease（CAD）,and to evaluate the impact of PCI on the inflammatory indice.Methods 70 patients undergoing PCI procedures for CAD with a single coronary artery were selected as PCI group,30 healthy individuals with normal findings by coronary angiography were selected as the control group.Before and after PCI or coronary angiography,plasm IL-6 and TNF-α were measured in all the subjects by enzyme-linked immune sorbent assay（ELISA）.Results Plasm IL-6 was（21.49±4.45） pg/L in PCI group after the PCI treatment,it was found higher than that before the PCI treatment,the difference was statistically significant（P 0.01）;IL-6 was（13.07±4.12） pg/L in control group,the difference was not statistically significant between before and after coronary angiography（P 0.05）.TNF-α was（15.67±4.25） ng/mL in PCI group after the PCI treatment,it was found higher than that before the PCI treatment（12.56±4.13） ng/mL,the difference was statistically significant（P 0.01）,TNF-α was（11.23±3.87） ng/mL in control group,the difference was not statistically significant between before and after coronary angiography（P 0.05）.Conclusion PCI procedures can elevate the plasma IL-6 and TNF-α in patients CAD,but their roles in the vascular restenosis following the procedures need further investigation.