帕利哌酮联合舍曲林治疗强迫症的对照研究

A control study of Paliperidone combining with Sertraline in treating obsessive-compulsive disorder

目的探讨帕利哌酮联合舍曲林治疗强迫症的疗效。方法将符合条件的56例强迫症患者随机分为帕利哌酮联合舍曲林组和单用舍曲林组,各28例,治疗12周。采用耶鲁-布朗强迫量表(Y-BOCS)和副反应量表(TESS)评定疗效和副反应。结果治疗结束后两组Y-BOCS评分均显著降低,而合用组更为明显,与舍曲林组比较差异具有统计学意义(13.18±4.16vs10.56±3.66,t=2.40,P<0.05)。治疗第6周末时,研究组副反应显著高于对照组(3.56±1.64vs2.68±1.27,t=2.18,P<0.05),而当治疗第12周末时两组副反应差异无统计学意义(2.83±1.45vs2.47±1.22,t=0.95,P>0.05)。结论帕利哌酮可以作为舍曲林增效剂治疗强迫症,增强疗效。

Objective To explore the efficacy of Paliperidone combining with Sertraline on patients with obsessive-com pulsive disorder （OCD）.Methods Fifty six patients with OCD who met the conditions were randomly divided into two groups.One group （n=28） was treated with Paliperidone combining with Sertraline,the other group （n=28） was treated with Sertraline only.The efficacy of treatment was measured with Yale-Brown obsessive Compulsive Scale （Y-BOCS） and Treatment Emergent Symptom Scale （TESS）.Results After treatment,Y-BOCS score of both groups were significantly reduced,and it was more apparent for the combined treatment group.There was significant difference compared with the Ser traline treated group （13.18±4.16 vs 10.56±3.66,t=2.40,P 0.05）.At the end of the sixth week,the side effects of study group were significantly higher than control group,while no significant difference of side effects were found between two groups at the end of the twelveth week （2.83±1.45 vs 2.47±1.22,t=0.95,P 0.05）.Conclusion Paliperidone can be used as a synergist of Sertraline in the treatment of obsessive-compulsive disorder to enhance the efficacy.