腹腔镜胆囊切除术对患者肝脏功能的影响

The influence of laparoscopic cholecystectomy on patients' liver function

目的观察腹腔镜胆囊切除术对患者肝脏功能的影响。方法本院需行胆囊切除术的64例患者,按照病情及患者意愿分为腹腔镜组38例及开腹组26例,腹腔镜组采取腹腔镜胆囊切除术,开腹组采取传统开腹胆囊切除术。观察两组术前、术后不同时间段血清总胆红素(T-BiL)、碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)变化。结果术前、术后1、3、5d两组间T-BiL、ALP、ALT、AST比较差异均无统计学意义(P>0.05);两组术后1、3dT-BiL、ALT、AST均较术前升高,两组与术前比较差异均有统计学意义(P<0.05);术后5dT-BiL、ALP、ALT、AST均与术前比较差异无统计学意义(P>0.05)。结论腹腔镜胆囊切除术后短期内对肝脏功能有所影响,但是术后5d均可恢复正常。腹腔镜胆囊切除是安全的。

Objective To observe the influence of laparoscopic cholecystectomy on patients＇ liver function.Methods Clinical data of 64 patients who need cholecystectomy were divided into laparoscopic group （38 cases） and open group （26 cas es） according to the condition and patients＇ will,patients in laparoscopic group were given laparoscopic cholecystectomy,while open group received the traditional open cystic resection.Serum total bilirubin （T-BiL）,alkaline phosphatase （ALP）,alanine amino shift enzyme （ALT）,aspartate amino shift enzyme （AST） change before surgery and in postoperative different period were observed.Results T-BiL,ALP,ALT,AST before operation and 3 d,1 d,5 d after opration between two groups had no statistical difference （P 0.05）;1 and 3 d after operation,T-BiL,ALT,AST rised in both two groups,there were statistical differences （P 0.05）;T-BiL,ALP,ALT,AST at 5 d after operation compared with the preoperative,there were no statistical differencse （P 0.05）.Conclusion Liver function may be influenced by laparoscopic cholecystectomy in short period after operation,but it can return to normal 5 d after operation.Laparoscopic cholecystectomy is safe.